Paired-agent imaging for measuring drug-target interactions in vivo

Kimberley S. Samkoe; Jonathan T. Elliott; Lei Wang; Summer Gibbs; Kenneth M. Tichauer

doi:10.1117/12.3008552

13 March 2024 Paired-agent imaging for measuring drug-target interactions in vivo

Kimberley S. Samkoe, Jonathan T. Elliott, Lei Wang, Summer Gibbs, Kenneth M. Tichauer

Proceedings Volume PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII; PC1282102 (2024) https://doi.org/10.1117/12.3008552
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The failure rate of drug development is high, especially in Phase III clinical trials after significant time and monetary investment. This can be observed in oncology trials, where drug failure rates are much higher than non-oncological trials due to inadequate improvement in overall survival. To address this problem, we propose the use of fluorescence paired-agent imaging (PAI) to monitor drug-receptor interactions in vivo in individual patients. Therapeutic agents can be conjugated to fluorophores used for measuring target-specific interactions. Our preclinical progress will be discussed for both oncology and non-oncology applications with promising translation to clinical applications in the future.

Conference Presentation

Citation Download Citation

Kimberley S. Samkoe, Jonathan T. Elliott, Lei Wang, Summer Gibbs, and Kenneth M. Tichauer "Paired-agent imaging for measuring drug-target interactions in vivo", Proc. SPIE PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII, PC1282102 (13 March 2024); https://doi.org/10.1117/12.3008552

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