Exploiting the optical absorption contrast of blood hemoglobin, photoacoustic microscopy (PAM) is an emerging technology for label-free imaging of the microvasculature, which plays an essential role in supplying biological tissue with oxygen and sustaining metabolic activity in vivo. The multi-parametric PAM developed in Dr. Hu’s lab enables comprehensive and quantitative characterization of microvascular structure, function, and tissue oxygen metabolism at the microscopic level. In this talk, Dr. Hu will present their latest progress on the development of PAM and the integration of PAM with other intravital light microscopy techniques for studying brain function and energy metabolism across spatiotemporal scales.
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