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Light-based in-vivo brain imaging relies on the transportation of light through highly scattering tissues over long distances. As scattering gradually reduces imaging contrast and resolution, it becomes challenging to visualize structures at greater depths, even when using multiphoton techniques. A recently proposed strategy involves the exploitation of holographic control of light transport through multimode optical fibres, which promises superior imaging performance combined with uniquely atraumatic application. Following the review of the fundamental and technological bases, the talk will introduce a 110μm thin laser-scanning endo-microscope, which enables volumetric imaging of the entire depth of the mouse brain in vivo.
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