Recovering tissue properties with a time-of-flight informed interferometric diffusing wave spectroscopy (iDWS) system

Mingjun Zhao; Santosh Aparanji; Vivek Srinivasan

doi:10.1117/12.3003039

13 March 2024 Recovering tissue properties with a time-of-flight informed interferometric diffusing wave spectroscopy (iDWS) system

Mingjun Zhao, Santosh Aparanji, Vivek Srinivasan

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Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280L (2024) https://doi.org/10.1117/12.3003039
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Diffuse optics often results in ill-posed inverse problems. Here we investigate a time-of-flight (TOF) informed interferometric diffuse optical approach, which applies a series of TOF filters to multiply scattered light collected via the human head. Rather than 1D data sets which are typical of diffuse optics, we obtain a 2D data set at a single source-collector separation, where the dimensions are TOF filter width and correlation time lag. We investigate recovery of optical properties, layer thicknesses, and blood flow indices by fitting a 3-layer model of the human head. We recover reasonable brain-to-scalp blood flow index ratios.

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Mingjun Zhao, Santosh Aparanji, and Vivek Srinivasan "Recovering tissue properties with a time-of-flight informed interferometric diffusing wave spectroscopy (iDWS) system", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280L (13 March 2024); https://doi.org/10.1117/12.3003039

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KEYWORDS

Interferometry

Tissues

Autocorrelation

Optical filters

Spectroscopy

Tunable filters

Data modeling

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