Bessel-beam OCM enables multiscale precision assessment of deep brain morpho-functional vessel changes

Lukas B. Glandorf; Bastian Wittmann; Jeanne Droux; Chaim Glueck; Bruno Weber; Susanne Wegener; Mohamad El-Amki; Rainer Leitgeb; Bjoern Menze; Daniel Razansky

doi:10.1117/12.3005633

13 March 2024 Bessel-beam OCM enables multiscale precision assessment of deep brain morpho-functional vessel changes

Lukas B. Glandorf, Bastian Wittmann, Jeanne Droux, Chaim Glueck, Bruno Weber, Susanne Wegener, Mohamad El-Amki, Rainer Leitgeb, Bjoern Menze, Daniel Razansky

Author Affiliations +

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128302I (2024) https://doi.org/10.1117/12.3005633
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

In this study, we present a refined xf-irOCM system and post-processing pipeline for detailed investigation of cerebral vessel structure and function. Our method uses deep learning for 3D segmentation of high- resolution angiograms and accurately estimates flow velocities across the cerebral vasculature. Our graph- based approach uniquely enables multiscale assessments, capturing data from intricate capillaries to broad network relationships. Specifically, it aids in understanding vascular alterations in neurovascular pathologies, such as stroke. Our approach will pave the way for future microvasculature studies, offering promising avenues for further research into neurovascular diseases.

Conference Presentation

Citation Download Citation

Lukas B. Glandorf, Bastian Wittmann, Jeanne Droux, Chaim Glueck, Bruno Weber, Susanne Wegener, Mohamad El-Amki, Rainer Leitgeb, Bjoern Menze, and Daniel Razansky "Bessel-beam OCM enables multiscale precision assessment of deep brain morpho-functional vessel changes", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128302I (13 March 2024); https://doi.org/10.1117/12.3005633

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Brain

Cerebrovascular diseases

Brain diseases

Capillaries

Deep learning

Doppler effect

In vivo imaging

Show All Keywords

Keywords/Phrases

Search In:

Publication Years