In vivo characterization of human tendon structure and function using multispectral optoacoustic tomography

Ivana Ivankovic; Hasiao-Chun Amy Lin; Ali Özbek; Ana Orive; Xose-Luis Deán-Ben; Daniel Razansky

doi:10.1117/12.3002632

13 March 2024 In vivo characterization of human tendon structure and function using multispectral optoacoustic tomography

Ivana Ivankovic, Hasiao-Chun Amy Lin, Ali Özbek, Ana Orive, Xose-Luis Deán-Ben, Daniel Razansky

Author Affiliations +

Proceedings Volume PC12838, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables V; PC1283804 (2024) https://doi.org/10.1117/12.3002632
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Despite tendon injury cases being on the rise globally, the lack of suitable non-invasive clinical imaging tools results in a lack of consensus for the best treatment option within the community. Here, we explore for the first time 4D multispectral optoacoustic tomography (MSOT) for non-invasive label-free evaluation of healthy human tendons, including the wrist flexors, ankle, and Achilles tendons. 3D morphology could be revealed in real-time, enabling motion tracking for the evaluation of tendon function dynamics. Furthermore, vasculature groups in and around the Achilles tendon could be visualized, and perfusion dynamics in response to localized exercise characterized. Unique in its ability to offer real-time, volumetric, label-free imaging with molecular contrast, and compounded by the method’s relatively low-cost, MSOT has been shown capable of assessing dynamic tendon morphology and haemodynamic physiology in response to controlled motion and exercise. Future studies including abnormal subjects could validate the method as a viable routine clinical tool for tendinopathy management and healing monitoring.

Conference Presentation

Citation Download Citation

Ivana Ivankovic, Hasiao-Chun Amy Lin, Ali Özbek, Ana Orive, Xose-Luis Deán-Ben, and Daniel Razansky "In vivo characterization of human tendon structure and function using multispectral optoacoustic tomography", Proc. SPIE PC12838, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables V, PC1283804 (13 March 2024); https://doi.org/10.1117/12.3002632

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