Functional OCT angiography reveals early retinal neurovascular dysfunction in diabetes with capillary resolution

Kaiyuan Liu; Peng Li

doi:10.1117/12.3002483

13 March 2024 Functional OCT angiography reveals early retinal neurovascular dysfunction in diabetes with capillary resolution

Kaiyuan Liu, Peng Li

Author Affiliations +

Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC1284108 (2024) https://doi.org/10.1117/12.3002483
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Altered retinal neurovascular coupling may contribute to the development and progression of diabetic retinopathy (DR) but remains highly challenging to measure. Here, we present a novel modality of functional OCT angiography (fOCTA) that allows a 3D imaging of retinal functional hyperemia across the entire vascular tree with single-capillary resolution. The high-resolution fOCTA revealed that the retinal capillaries exhibited apparent hyperemic response in normal mice and significant functional hyperemia loss at an early stage of DR and visible restoration after aminoguanidine treatment. The proposed retinal fOCTA would provide new insights into the pathophysiology, screening, and treatment of early DR.

Conference Presentation

Citation Download Citation

Kaiyuan Liu and Peng Li "Functional OCT angiography reveals early retinal neurovascular dysfunction in diabetes with capillary resolution", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC1284108 (13 March 2024); https://doi.org/10.1117/12.3002483

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