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13 March 2024 Assessment of bone health through a photoacoustic quantitative ultrasound (PAQUS) apparatus: a preliminary phantom and clinical study
Zhanpeng Xu, Duane Kaufman, Rich Hogle, Dave Nelson, Conor Locke, Dara Geva, DeAndre Jamison, Rich Morris, Kenneth Kozloff, Xueding Wang
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Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128421D (2024) https://doi.org/10.1117/12.2692832
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
In this work, a novel PAQUS apparatus was developed for in vivo assessment of the calcaneus. We first made lattice-shaped cubic phantoms of varying density, resulting in different BVF. PA absorbance at 740 nm (hemoglobin) and 930 nm (lipid) were significantly different across phantoms. Next, we created two anatomic phantoms based on a human calcaneus microCT volumetric image, and artificially eroded the trabecular structure on one to reduce BVF by 32.5%, mimicking osteoporosis-mediated bone loss. Phantoms were measured repeatedly and also significantly differed. Lastly, in vivo bilateral PA measurement was conducted at the calcaneus on 32 female Caucasian subjects (20-74 yrs). A significant difference in PA absorption was observed at 740 nm between younger (<50 yrs) and older (>50 yrs) subjects.
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Zhanpeng Xu, Duane Kaufman, Rich Hogle, Dave Nelson, Conor Locke, Dara Geva, DeAndre Jamison, Rich Morris, Kenneth Kozloff, and Xueding Wang "Assessment of bone health through a photoacoustic quantitative ultrasound (PAQUS) apparatus: a preliminary phantom and clinical study", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128421D (13 March 2024); https://doi.org/10.1117/12.2692832
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KEYWORDS
Bone
Photoacoustic spectroscopy
Ultrasonography
Diseases and disorders
In vivo imaging
Osteoporosis
Reflection
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