Ultra-wildfield high-speed dual view photoacoustic microscopy for life sciences

Van Tu Nguyen; Tri Vu; Soon Woo Cho; Ilaria Merutka; Nishad Jayasundara; Carlos Taboada; Junjie Yao

doi:10.1117/12.3002609

13 March 2024 Ultra-wildfield high-speed dual view photoacoustic microscopy for life sciences

Van Tu Nguyen, Tri Vu, Soon Woo Cho, Ilaria Merutka, Nishad Jayasundara, Carlos Taboada, Junjie Yao

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128421L (2024) https://doi.org/10.1117/12.3002609
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present a novel implementation of high-speed photoacoustic microscopy with an ultrawide field of view (FOV). Existing photoacoustic microscopy systems have limitations in resolution, FOV, and speed. To address these challenges, we improved our previous immersible-polygon-scanner-based photoacoustic microscopy and developed a dual-view photoacoustic microscopy system using two facets of the same scanner. The system has achieved high resolutions of ~10 µm (lateral) and 35 µm (axial) with a B-scan rate of 500 Hz. We have demonstrated the imaging performance on freely-moving zebrafish and hypoxia challenge of a pair of mice.

Conference Presentation

Citation Download Citation

Van Tu Nguyen, Tri Vu, Soon Woo Cho, Ilaria Merutka, Nishad Jayasundara, Carlos Taboada, and Junjie Yao "Ultra-wildfield high-speed dual view photoacoustic microscopy for life sciences", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128421L (13 March 2024); https://doi.org/10.1117/12.3002609

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