Rational design of ICG-based contrast agents for near-infrared photoacoustic imaging

Marzieh Hanafi; Nicholas Such; Giovanni Giammanco; Shrishti Singh; Dana Wegierak; Eric Abenojar; Pinunta Nittayacharn; Tessa Kosmides; Agata A. Exner; Remi Veneziano; Parag V. Chitnis

doi:10.1117/12.3003260

13 March 2024 Rational design of ICG-based contrast agents for near-infrared photoacoustic imaging

Marzieh Hanafi, Nicholas Such, Giovanni Giammanco, Shrishti Singh, Dana Wegierak, Eric Abenojar, Pinunta Nittayacharn, Tessa Kosmides, Agata A. Exner, Remi Veneziano, Parag V. Chitnis

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284220 (2024) https://doi.org/10.1117/12.3003260
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Near-infrared Photoacoustic imaging (NIR-PA) can enable deep-tissue imaging, yet clinical translation has been hindered by a lack of suitable NIR-PA contrast agents. The FDA-approved Indocyanine green (ICG) dye is a promising candidate, but it offers limited targeting ability and poor stability. To address this unmet need, we examined three novel ICG-based platforms in the form of DNA scaffolds, J-aggregates, and nanobubbles. We demonstrate that all three platforms yield a PA signal stronger than whole blood at concentrations as low as 45 µM and are amenable to molecular targeting.

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Marzieh Hanafi, Nicholas Such, Giovanni Giammanco, Shrishti Singh, Dana Wegierak, Eric Abenojar, Pinunta Nittayacharn, Tessa Kosmides, Agata A. Exner, Remi Veneziano, and Parag V. Chitnis "Rational design of ICG-based contrast agents for near-infrared photoacoustic imaging", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284220 (13 March 2024); https://doi.org/10.1117/12.3003260

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