Improved acoustic resolution photoacoustic endoscopy system for colorectal cancer treatment monitoring.

Sanskar Thakur; Sitai Kou; Ahmed Eltahir; Lukai Wang; Andrew Song; Yitian Zhang; Haolin Nie; Yixiao Lin; William Chapman Jr.; Quing Zhu

doi:10.1117/12.3023328

13 March 2024 Improved acoustic resolution photoacoustic endoscopy system for colorectal cancer treatment monitoring.

Sanskar Thakur, Sitai Kou, Ahmed Eltahir, Lukai Wang, Andrew Song, Yitian Zhang, Haolin Nie, Yixiao Lin, William Chapman Jr., Quing Zhu

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284227 (2024) https://doi.org/10.1117/12.3023328
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Colorectal cancer ranks as the second most prevalent global malignancy and stands as the fourth leading cause of cancer-related deaths in the United States. The ability to accurately monitor rectal cancer treatment responses poses a significant challenge given the limitations of existing imaging modalities in confirming pathological complete response after chemoradiation. Non-invasive confirmation of complete response can offer improved quality of life, reduced medical costs, and decreased strain on the healthcare system for patients. Previous findings from our research group highlighted the potential of co-registered acoustic-resolution Photoacoustic Microscopy (ARPAM) and ultrasound (ARPAM/US) in monitoring treatment response, revealing the recovery of regular microvascular patterns in the tumor bed through photoacoustic microscopy in treatment responders. In this presentation, we introduce a second-generation compact and robust ARPAM/US system designed for monitoring rectal cancer treatment responses in an endoscopy unit suitable for repeated imaging. We will present a comparative analysis between normal tissue and tumor bed with and without residual tumor after chemoradiation.

Citation Download Citation

Sanskar Thakur, Sitai Kou, Ahmed Eltahir, Lukai Wang, Andrew Song, Yitian Zhang, Haolin Nie, Yixiao Lin, William Chapman Jr., and Quing Zhu "Improved acoustic resolution photoacoustic endoscopy system for colorectal cancer treatment monitoring.", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284227 (13 March 2024); https://doi.org/10.1117/12.3023328

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