Total peptide-based photoacoustic contrast agent enabled by Lepidium virginicum water-soluble chlorophyll-binding protein (LvP)

Victor T. C. Tsang; Hayeon Hannah Kim; Bingxin Huang; Simon C. K. Chan; Terence T. W. Wong

doi:10.1117/12.3002092

13 March 2024 Total peptide-based photoacoustic contrast agent enabled by Lepidium virginicum water-soluble chlorophyll-binding protein (LvP)

Victor T. C. Tsang, Hayeon Hannah Kim, Bingxin Huang, Simon C. K. Chan, Terence T. W. Wong

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128422W (2024) https://doi.org/10.1117/12.3002092
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

This work introduces a total-peptide-based contrast agent for deep-tissue photoacoustic imaging, addressing the limitations of conventional imaging techniques. Chlorophyll a (Chla) was selected for its light-harvesting ability and solubilized using the Leipidium virginicum water-soluble chlorophyll-binding protein (LvP). LvP-chla enables clear visualization in vivo, discernible from the blood via spectroscopic PA imaging. LvP-chla showed promise as a favorable candidate for clinical photoacoustic imaging applications.

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Victor T. C. Tsang, Hayeon Hannah Kim, Bingxin Huang, Simon C. K. Chan, and Terence T. W. Wong "Total peptide-based photoacoustic contrast agent enabled by Lepidium virginicum water-soluble chlorophyll-binding protein (LvP)", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128422W (13 March 2024); https://doi.org/10.1117/12.3002092

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