1070-nm light attenuates Aβ burden and cognitive impairments in Alzheimer’s disease mouse model

Xunbin Wei

doi:10.1117/12.3005203

13 March 2024 1070-nm light attenuates Aβ burden and cognitive impairments in Alzheimer’s disease mouse model

Xunbin Wei

Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC1284301 (2024) https://doi.org/10.1117/12.3005203
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Photobiomodulation (PBM), utilizing the low power light in visible or near-infrared (NIR) spectrum to trigger biological responses in the cells and tissues, has been considered as a possible therapeutic strategy for Alzheimer’s disease (AD), while its specific mechanism has remained elusive. Here, we provide evidences that the cognition and memory impairment of AD mouse model can be ameliorated by 1070-nm light via reducing cerebral Aβ burden, the hallmark of AD. Our study suggests the important roles of microglia and cerebral vessels in the treatment of 1070-nm light to AD mice, and provide a framework for developing novel therapeutic approach for AD.

Conference Presentation

Citation Download Citation

Xunbin Wei "1070-nm light attenuates Aβ burden and cognitive impairments in Alzheimer’s disease mouse model", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC1284301 (13 March 2024); https://doi.org/10.1117/12.3005203

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available