Investigating links between viscoelastic and microstructural characteristics of blood clots in patients with coagulation impairments

Nathaniel Hai; Ziqian Zeng; Eli Foster; Dvir Yelin; Seemantini K. Nadkarni

doi:10.1117/12.3003541

13 March 2024 Investigating links between viscoelastic and microstructural characteristics of blood clots in patients with coagulation impairments

Nathaniel Hai, Ziqian Zeng, Eli Foster, Dvir Yelin, Seemantini K. Nadkarni

Author Affiliations +

Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC128440C (2024) https://doi.org/10.1117/12.3003541
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The viscoelastic properties and microstructure of the fibrin clot network are compromised in patients with coagulation abnormalities. In this study, we harness two novel optical approaches, iCoagLab and Spectrally Encoded Confocal Microscopy (SECM), to investigate how modifications in viscoelastic properties of blood clots are reflected in the microstructural features of the fibrin network in coagulopathic patients. We observe that blood clot viscoelasticity is directly related to fibrin density, fiber length, and fiber straightness of a fully polymerized fibrin network.

Conference Presentation

Citation Download Citation

Nathaniel Hai, Ziqian Zeng, Eli Foster, Dvir Yelin, and Seemantini K. Nadkarni "Investigating links between viscoelastic and microstructural characteristics of blood clots in patients with coagulation impairments", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440C (13 March 2024); https://doi.org/10.1117/12.3003541

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