High-speed visible light optical coherence tomography for high resolution structural and elastographic imaging in the cornea

Lucas May; Sarah Nagl; Antonia Lichtenegger; Conrad Merkle; Andreas Drauschke; Bernhard Baumann

doi:10.1117/12.3002508

18 March 2024 High-speed visible light optical coherence tomography for high resolution structural and elastographic imaging in the cornea

Lucas May, Sarah Nagl, Antonia Lichtenegger, Conrad Merkle, Andreas Drauschke, Bernhard Baumann

Author Affiliations +

Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC128440K (2024) https://doi.org/10.1117/12.3002508
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Irregularities of ocular pulsatility are associated with some of the most severe eye diseases. Here, we present a high-speed visible light OCT for simultaneous high-resolution structural imaging and measuring local heartbeat-induced micro-displacements in corneas of rodents. The analysis of complex OCT signal dynamics across repeated frame acquisitions enables tissue motion measurements with high spatial and temporal resolution. As a proof of concept, we demonstrate in vivo imaging in corneas of wildtype mice and reveal subtle structural deformations related to ocular pulsation. Our data in mouse eyes hold promise for a passive, noncontact elastography technique that may enable a new paradigm of OCT based measurements and image contrast.

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Lucas May, Sarah Nagl, Antonia Lichtenegger, Conrad Merkle, Andreas Drauschke, and Bernhard Baumann "High-speed visible light optical coherence tomography for high resolution structural and elastographic imaging in the cornea", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440K (18 March 2024); https://doi.org/10.1117/12.3002508

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KEYWORDS

Cornea

Optical coherence tomography

Structural imaging

Tissues

Visible radiation

Corneal imaging

Image resolution

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