Deyan Ivanov,1 Lu Si,2 Leonard Felger,3 Theoni Maragkou,4 Philippe Schucht,3 Marie-Claire Schanne-Klein,5 Hui Ma,6,7 Razvigor Ossikovski,1 Tatiana Novikovahttps://orcid.org/0000-0002-9048-91581,8
1Lab. de Physique des Interfaces et des Couches Minces (France) 2Tsinghua-Berkeley Shenzhen Institute, Tsinghua Univ. (China) 3Inselspital, Univ. Bern (Switzerland) 4Institut für Gewebemedizin und Pathologie, Univ. Bern (Switzerland) 5Lab. d'Optique et Biosciences, CNRS (France) 6Tsinghua-Berkeley Shenzhen Institute (China) 7Tsinghua Univ. (China) 8Florida International Univ. (United States)
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Wide-field Imaging Mueller polarimetry (IMP) is capable to trace the in-plane orientation of brain fiber tracts by detecting the retardance of healthy brain white matter. IMP can help delineating brain tumor during neurosurgery, because tumor cells grow chaotically. However, the underlying crossing fibers may also affect the retardance of healthy brain. We measured with the transmission Mueller microscope two-layered stacks of thin sections of brain corpus callosum tissue. Brain fiber crossing induced the drop in the linear retardance values and azimuth randomization. The depolarization was invariant to mutual orientation of corpus callosum stripes, hence, the studies of brain tumor depolarization may help to distinguish brain tumor from the fiber crossing zones.
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Deyan Ivanov, Lu Si, Leonard Felger, Theoni Maragkou, Philippe Schucht, Marie-Claire Schanne-Klein, Hui Ma, Razvigor Ossikovski, Tatiana Novikova, "Polarimetric images of human brain histological sections: impact of nerve fiber bundles crossing," Proc. SPIE PC12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024, PC1284506 (13 March 2024); https://doi.org/10.1117/12.3004218