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13 March 2024 Depth-resolved Mueller matrix analysis of cervical remodeling in pregnant mice
Ajmal Ajmal, JunZhu Pei, Amanda Sanchez, Jessica Ramella-Roman
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Proceedings Volume PC12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024; PC1284508 (2024) https://doi.org/10.1117/12.3005367
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The uterine cervix undergoes extensive remodeling during pregnancy to facilitate successful childbirth. The extracellular matrix (ECM) plays a pivotal role in this remodeling process, affecting cervical biomechanics and its ability to maintain structural integrity throughout gestation. However, early softening of the uterine cervix due to accelerated remodeling of the cervix ECM leads to Preterm Birth. In this study, we performed Mueller matrix polarization imaging of mice cervix at different pregnancy time points and analyzed polarization parameters to assess the associated cervical collagen remodeling. Our research focuses on the depth-resolved Mueller matrix polarization assessment of the ECM structure evolution of mice cervix sections, spanning from external OS to the internal OS of the cervical region, at different gestation stages. Our statistical analysis of the MM results yields valuable information on the variation in the micro-structural organization of the cervical ECM across depths.
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Ajmal Ajmal, JunZhu Pei, Amanda Sanchez, and Jessica Ramella-Roman "Depth-resolved Mueller matrix analysis of cervical remodeling in pregnant mice", Proc. SPIE PC12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024, PC1284508 (13 March 2024); https://doi.org/10.1117/12.3005367
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KEYWORDS
Mueller matrices
Cervix
Polarization
Polarization imaging
Collagen
Polarimetry
Reflection
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