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13 March 2024 Imaging colloidal gold nanorod and microparticle agglutination with lens-free holographic microscopy for biomolecule sensing
Colin J. Potter, Euan McLeod
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Proceedings Volume PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics; PC1285006 (2024) https://doi.org/10.1117/12.3003197
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Healthcare disparities revealed during the COVID-19 pandemic must be addressed. A simple way to enable care to reach remote or low-resource communities is through inexpensive, rapid, sensitive, and portable biosensors. Here, we discuss work on the development and testing of a lens-free holographic microscopy (LFHM) and agglutination assay-based biosensor capable of rapid and sensitive point-of-care detection of SARS-CoV-2 virus. Additionally, we discuss recent efforts to further improve this sensor by using colloidal gold nanorods and machine learning approaches.
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Colin J. Potter and Euan McLeod "Imaging colloidal gold nanorod and microparticle agglutination with lens-free holographic microscopy for biomolecule sensing", Proc. SPIE PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics, PC1285006 (13 March 2024); https://doi.org/10.1117/12.3003197
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KEYWORDS
Biosensors
Gold nanorods
Holography
Microscopy
Biomolecules
Biosensing
Diseases and disorders
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