High contrast targeted SWIR fluorescence tumor screening and resection with a commercially available dye

Ben Mc Larney; Elana Apfelbaum; Ali Sonay; Magdalena Skubal; Mijin Kim; Hsiao-Ting Tsu; Daniel Heller; Jan Grimm

doi:10.1117/12.3000503

13 March 2024 High contrast targeted SWIR fluorescence tumor screening and resection with a commercially available dye

Ben Mc Larney, Elana Apfelbaum, Ali Sonay, Magdalena Skubal, Mijin Kim, Hsiao-Ting Tsu, Daniel Heller, Jan Grimm

Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620I (2024) https://doi.org/10.1117/12.3000503
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Here we have validated a commercially available dye, CJ215 from ProImaging for enhanced cancer delineation. The dye (which does not require antibody or peptide conjugation) was found to be effective for both NIR and SWIR fluorescence imaging methods in preclinical breast, fibrosarcoma and prostate tumor models. The dye was effective for screening and resection and achieved some of the best-in-class tumor to organ ratios, e.g., tumor to muscle of 88.1, to liver of 17.9, to lungs of 12.9 and to kidney of 5 highlighting its renal clearance method. We briefly summarize the proposed mechanism of uptake and highlight the potential for clinical translation.

Conference Presentation

Citation Download Citation

Ben Mc Larney, Elana Apfelbaum, Ali Sonay, Magdalena Skubal, Mijin Kim, Hsiao-Ting Tsu, Daniel Heller, and Jan Grimm "High contrast targeted SWIR fluorescence tumor screening and resection with a commercially available dye", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620I (13 March 2024); https://doi.org/10.1117/12.3000503

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