Aligned printing on and in various chips for biological applications

Benjamin Richter; Marc Hippler; Remmi Baker-Sediako; Andrea Bertoncini; Mareike Trappen; Matthias Blaicher; Fabian Niesler; Michael Thiel

doi:10.1117/12.3002466

13 March 2024 Aligned printing on and in various chips for biological applications

Benjamin Richter, Marc Hippler, Remmi Baker-Sediako, Andrea Bertoncini, Mareike Trappen, Matthias Blaicher, Fabian Niesler, Michael Thiel

Author Affiliations +

Proceedings Volume PC12876, Laser 3D Manufacturing XI; PC1287601 (2024) https://doi.org/10.1117/12.3002466
Event: SPIE LASE, 2024, San Francisco, California, United States

Abstract

Herein, we demonstrate the translation of Two-Photon Grayscale Lithography (2GL®), as well as Aligned 2-Photon Lithography (A2PL®), to biomedical applications. Specifically, we will present a novel workflow of aligned two-photon polymerization (2PP) microfabrication for 3D cell assays and perfusion inside microfluidic devices. For completeness, we also reveal how 2GL® can be applied to artificial intelligence (AI) generated topographies for enhanced and scalable 2.5D cell culturing. The versatility offered by both aligned and 2GL® printing holds great promise for various applications in biotechnology, tissue engineering, and microfluidics, creating new opportunities for innovation within established biomedical and pharmaceutical industries.

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Citation Download Citation

Benjamin Richter, Marc Hippler, Remmi Baker-Sediako, Andrea Bertoncini, Mareike Trappen, Matthias Blaicher, Fabian Niesler, and Michael Thiel "Aligned printing on and in various chips for biological applications", Proc. SPIE PC12876, Laser 3D Manufacturing XI, PC1287601 (13 March 2024); https://doi.org/10.1117/12.3002466

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