Micro-scale assessment of breast cancer elasticity using optical coherence elastography

Rowan W. Sanderson; Ken Y. Foo; Renate Zilkens; Imogen Boman; Lee Jackson; Jose Cid Fernandez; Benjamin F. Dessauvagie; Chris Yeomans; Anmol Rijhumal; Saud Hamza; Christobel M. Saunders; Brendan F. Kennedy

doi:10.1117/12.3016862

20 June 2024 Micro-scale assessment of breast cancer elasticity using optical coherence elastography

Rowan W. Sanderson, Ken Y. Foo, Renate Zilkens, Imogen Boman, Lee Jackson, Jose Cid Fernandez, Benjamin F. Dessauvagie, Chris Yeomans, Anmol Rijhumal, Saud Hamza, Christobel M. Saunders, Brendan F. Kennedy

Author Affiliations +

Proceedings Volume PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III; PC130060J (2024) https://doi.org/10.1117/12.3016862
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Optical coherence elastography (OCE) is an imaging technique capable of mapping mechanical properties (such as elasticity) in 3-D and is emerging as a valuable tool in the study and potential intraoperative diagnosis of breast cancer due to mechanical contrast between healthy and malignant tissue. While the correlation between elevated elasticity in OCE and breast cancers has been well established, these studies have primarily focused on binary classifications of tissue as either malignant or benign, ignoring much of the heterogeneity present in breast tissue. In this work, we present a detailed assessment of the microstructures present in human breast tissue images acquired with OCE, identifying regions of interest that corresponded to invasive carcinomas, in situ carcinomas and benign tissue types. We also describe the unique morphological patterns present in each tissue type and provide a framework for the interpretation of breast cancer images acquired with OCE.

Conference Presentation

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Rowan W. Sanderson, Ken Y. Foo, Renate Zilkens, Imogen Boman, Lee Jackson, Jose Cid Fernandez, Benjamin F. Dessauvagie, Chris Yeomans, Anmol Rijhumal, Saud Hamza, Christobel M. Saunders, and Brendan F. Kennedy "Micro-scale assessment of breast cancer elasticity using optical coherence elastography", Proc. SPIE PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III, PC130060J (20 June 2024); https://doi.org/10.1117/12.3016862

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