Clinical-compatible stimulated Raman imaging device for intraoperative histology of fresh tissue samples

Maximilian Brinkmann; Maryam Rezaei; Ramon Droop; Christoph Engwer; Felix Neumann; Niklas Lüpken; Sven Dopner; Tim Hellwig

doi:10.1117/12.3022477

19 June 2024 Clinical-compatible stimulated Raman imaging device for intraoperative histology of fresh tissue samples

Maximilian Brinkmann, Maryam Rezaei, Ramon Droop, Christoph Engwer, Felix Neumann, Niklas Lüpken, Sven Dopner, Tim Hellwig

Author Affiliations +

Proceedings Volume PC13009, Clinical Biophotonics III; PC130090K (2024) https://doi.org/10.1117/12.3022477
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

We present a fully integrated, clinical-compatible SRS imaging device giving access to the complete Raman spectrum during tumor surgeries. Leveraging the advantages of a compact and robust fiber laser, we have integrated the entire microscopy system into a clinical cart, facilitating deployment in diverse clinical environments. The laser provides rapid tunability within milliseconds across a broad spectral range of 700 to 3300 cm^-1, covering biomedically relevant resonances in the fingerprint region. For detailed examination of larger tissue samples, we have designed a high-speed, low-resolution imaging mode to quickly identify cancerous hot-spots, followed by a high-resolution imaging mode.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Maximilian Brinkmann, Maryam Rezaei, Ramon Droop, Christoph Engwer, Felix Neumann, Niklas Lüpken, Sven Dopner, and Tim Hellwig "Clinical-compatible stimulated Raman imaging device for intraoperative histology of fresh tissue samples", Proc. SPIE PC13009, Clinical Biophotonics III, PC130090K (19 June 2024); https://doi.org/10.1117/12.3022477

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