Single-shot off-axis full-field optical coherence tomography (SO-FF-OCT) method for in-vivo tomographic imaging and shear wave elastography

Emmanuel Martins Seromenho; Nina Dufour; Maud Legrand; Jesse Schiffler; Vincent Maioli; Sybille Facca; Nadia Bahlouli; Amir Nahas

doi:10.1117/12.3013068

19 June 2024 Single-shot off-axis full-field optical coherence tomography (SO-FF-OCT) method for in-vivo tomographic imaging and shear wave elastography

Emmanuel Martins Seromenho, Nina Dufour, Maud Legrand, Jesse Schiffler, Vincent Maioli, Sybille Facca, Nadia Bahlouli, Amir Nahas

Author Affiliations +

Proceedings Volume PC13010, Tissue Optics and Photonics III; PC130100E (2024) https://doi.org/10.1117/12.3013068
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Over the past few decades, a multitude of optical imaging techniques have emerged. Among them, full-field optical coherence tomography (FF-OCT) has gained significant importance in various biomedical applications. Indeed, FF-OCT stands out as a noninvasive and label-free imaging method capable of generating high-resolution 3D microscopic images of light-scattering biological specimens. However, FF-OCT approach is limited for in-vivo imaging and images from FF-OCT lack the specificity required for accurate diagnosis. Hence, there is a need to have access to in-vivo imaging and to incorporate additional contrast modalities, such as elastography, into the FF-OCT technique. Indeed, the combination of FF-OCT with shear wave elastography enables the quantitative assessment of tissue stiffness at a resolution of a few micrometers. In this context, we present a novel FF-OCT approach that enables single-shot acquisitions, making it well-suited for both in-vivo imaging and transient shear wave elastography.

Conference Presentation

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Emmanuel Martins Seromenho, Nina Dufour, Maud Legrand, Jesse Schiffler, Vincent Maioli, Sybille Facca, Nadia Bahlouli, and Amir Nahas "Single-shot off-axis full-field optical coherence tomography (SO-FF-OCT) method for in-vivo tomographic imaging and shear wave elastography", Proc. SPIE PC13010, Tissue Optics and Photonics III, PC130100E (19 June 2024); https://doi.org/10.1117/12.3013068

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KEYWORDS

Elastography

In vivo imaging

Biological imaging

Optical coherence tomography

Biomedical optics

Tomography

Biological samples

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