Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer

Roger J. Zemp; Rachel Bitton; K. Kirk Shung; Meng-Lin Li; George Stoica D.V.M.; Lihong V. Wang

doi:10.1117/1.2709850

1 January 2007 Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer

Roger J. Zemp, Rachel Bitton, K. Kirk Shung, Meng-Lin Li, George Stoica D.V.M., Lihong V. Wang

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Journal of Biomedical Optics, Vol. 12, Issue 1, 010501 (January 2007). https://doi.org/10.1117/1.2709850

Abstract

Visualization of microvascular networks could provide new information about function and disease. We demonstrate the capabilities of a 30-MHz ultrasound array system for photoacoustic microscopy of small (≤300 μm) vessels in a rat. 3D images obtained by translating the array in the elevation direction are compared with photographs of excised skin. The system is shown to have 100-μm lateral resolution, 25-μm axial resolution, and 3-mm imaging depth. To our knowledge this is the first report on photoacoustic microscopy of the microvasculature with a high-frequency array transducer. It is anticipated that the system can be used for studying and diagnosing a number of diseases including cancer, atherosclerosis, dermatological disorders, and peripheral microvascular complications in diabetes.

©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Roger J. Zemp, Rachel Bitton, K. Kirk Shung, Meng-Lin Li, George Stoica D.V.M., and Lihong V. Wang "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," Journal of Biomedical Optics 12(1), 010501 (1 January 2007). https://doi.org/10.1117/1.2709850

Published: 1 January 2007

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