Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy

Erich W. Stein; Konstantin I. Maslov; Lihong V. Wang

doi:10.1117/1.3095799

1 March 2009 Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy

Erich W. Stein, Konstantin I. Maslov, Lihong V. Wang

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Journal of Biomedical Optics, Vol. 14, Issue 2, 020502 (March 2009). https://doi.org/10.1117/1.3095799

Abstract

Photoacoustic microscopy (PAM) has been used to obtain high-resolution, noninvasive images of the in vivo mouse brain. In this work, we exploit the high-depth and temporal resolutions of PAM to noninvasively image the blood-oxygenation dynamics of multiple cortex vessels in the mouse brain simultaneously in response to controlled hypoxic and hyperoxic challenges. These results confirm the ability of PAM to track blood oxygenation in the mouse brain, a critical aspect of imaging brain activity through the hemodynamic response.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Erich W. Stein, Konstantin I. Maslov, and Lihong V. Wang "Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy," Journal of Biomedical Optics 14(2), 020502 (1 March 2009). https://doi.org/10.1117/1.3095799

Published: 1 March 2009

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