Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes

Feifan Zhou; Xing Da; Zhongmin Ou; Baoyan Wu; Daniel E. Resasco; Wei R. Chen

doi:10.1117/1.3078803

1 March 2009 Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes

Feifan Zhou, Xing Da, Zhongmin Ou, Baoyan Wu, Daniel E. Resasco, Wei R. Chen

Author Affiliations +

Journal of Biomedical Optics, Vol. 14, Issue 2, 021009 (March 2009). https://doi.org/10.1117/1.3078803

Abstract

Single-walled carbon nanotubes (SWNTs) have a high optical absorbance in the near-infrared (NIR) region. In this special optical window, biological systems are known to be highly transparent. The optical properties of SWNTs provide an opportunity for selective photothermal therapy for cancer treatment. Specifically, CoMoCAT^® nanotubes with a uniform size (about 0.81 nm) and a narrow absorption peak at 980 nm are ideal candidates for such a novel approach. Here, CoMoCAT^® SWNTs are conjugated to folate, which can bind specifically to the surface of the folate receptor tumor markers. Folate-SWNT (FA-SWNT) targeted tumor cells were irradiated by a 980-nm laser. In our in vitro and in vivo experiments, FA-SWNT effectively enhanced the photothermal destruction on tumor cells and noticeably spared the photothermal destruction for nontargeted normal cells. Thus, SWNTs, combined with suitable tumor markers, can be used as novel nanomaterials for selective photothermal therapy for cancer treatment.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Feifan Zhou, Xing Da, Zhongmin Ou, Baoyan Wu, Daniel E. Resasco, and Wei R. Chen "Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes," Journal of Biomedical Optics 14(2), 021009 (1 March 2009). https://doi.org/10.1117/1.3078803

Published: 1 March 2009

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KEYWORDS

Single walled carbon nanotubes

Tumors

Cancer

Laser therapeutics

Absorption

Cell death

Tissues

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