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1 March 2009 Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy
Georgy Sergeevich Terentyuk, Galina N. Maslyakova, Leyla V. Suleymanova, Nikolay Grigorievich Khlebtsov, Boris Nokolaevich Khlebtsov, Garif Gazizovich Akchurin, Irina Leonidovna Maksimova, Valery V. Tuchin
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Journal of Biomedical Optics, Vol. 14, Issue 2, 021016 (March 2009). https://doi.org/10.1117/1.3122371
Abstract
We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affectations by the laser radiation are measured in vivo with a thermal imaging system. The results of temperature measurements are compared with tissue histology.
©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Georgy Sergeevich Terentyuk, Galina N. Maslyakova, Leyla V. Suleymanova, Nikolay Grigorievich Khlebtsov, Boris Nokolaevich Khlebtsov, Garif Gazizovich Akchurin, Irina Leonidovna Maksimova, and Valery V. Tuchin "Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy," Journal of Biomedical Optics 14(2), 021016 (1 March 2009). https://doi.org/10.1117/1.3122371
Published: 1 March 2009
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Cited by 194 scholarly publications and 4 patents.
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KEYWORDS
Nanoparticles
Gold
Tissues
Laser tissue interaction
Particles
Temperature metrology
Skin
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