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1 January 2010 Real-time photoacoustic tomography of cortical hemodynamics in small animals
Changhui Li, Andres Aguirre, John K. Gamelin, Anastasios Maurudis, Quing Zhu, Lihong V. Wang
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Journal of Biomedical Optics, Vol. 15, Issue 1, 010509 (January 2010). https://doi.org/10.1117/1.3302807
Abstract
For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities.
©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Changhui Li, Andres Aguirre, John K. Gamelin, Anastasios Maurudis, Quing Zhu, and Lihong V. Wang "Real-time photoacoustic tomography of cortical hemodynamics in small animals," Journal of Biomedical Optics 15(1), 010509 (1 January 2010). https://doi.org/10.1117/1.3302807
Published: 1 January 2010
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Cited by 124 scholarly publications and 1 patent.
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KEYWORDS
Acquisition tracking and pointing
Photoacoustic tomography
Absorption
Hemodynamics
In vivo imaging
Ultrasonography
Photoacoustic spectroscopy
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