Photoacoustic and high-frequency power Doppler ultrasound biomicroscopy: a comparative study

Yan Jiang; Tyler Harrison; Janaka C. Ranasinghesagara; Roger J. Zemp

doi:10.1117/1.3491126

1 September 2010 Photoacoustic and high-frequency power Doppler ultrasound biomicroscopy: a comparative study

Yan Jiang, Tyler Harrison, Janaka C. Ranasinghesagara, Roger J. Zemp

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Journal of Biomedical Optics, Vol. 15, Issue 5, 056008 (September 2010). https://doi.org/10.1117/1.3491126

Abstract

Both photoacoustic imaging and power Doppler ultrasound are capable of producing images of the vasculature of living subjects, however, the contrast mechanisms of the two modalities are very different. We present a quantitative and objective comparison of the two methods using phantom data, highlighting relative merits and shortcomings. An imaging system for combined photoacoustic and high-frequency power Doppler ultrasound microscopy is presented. This system uses a swept-scan 25-MHz ultrasound transducer with confocal dark-field laser illumination optics. A pulse-sequencer enables ultrasonic and laser pulses to be interlaced so that photoacoustic and power Doppler ultrasound images can be coregistered. Experiments are performed on flow phantoms with various combinations of vessel size, flow velocity, and optical wavelength. For the task of blood volume detection, power Doppler is seen to be advantageous for large vessels and high flow speeds. For small vessels with low flow speeds, photoacoustic imaging is seen to be more effective than power Doppler at the detection of blood as quantified by receiver operating characteristic analysis. A combination of the two modes could provide improved estimates of fractional blood volume in comparison with either mode used alone.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Yan Jiang, Tyler Harrison, Janaka C. Ranasinghesagara, and Roger J. Zemp "Photoacoustic and high-frequency power Doppler ultrasound biomicroscopy: a comparative study," Journal of Biomedical Optics 15(5), 056008 (1 September 2010). https://doi.org/10.1117/1.3491126

Published: 1 September 2010

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