Depth-correction algorithm that improves optical quantification of large breast lesions imaged by diffuse optical tomography

Behnoosh Tavakoli; Quing Zhu

doi:10.1117/1.3573814

1 May 2011 Depth-correction algorithm that improves optical quantification of large breast lesions imaged by diffuse optical tomography

Behnoosh Tavakoli, Quing Zhu

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 5, 056002 (May 2011). https://doi.org/10.1117/1.3573814

Abstract

Optical quantification of large lesions imaged with diffuse optical tomography in reflection geometry is depth dependence due to the exponential decay of photon density waves. We introduce a depth-correction method that incorporates the target depth information provided by coregistered ultrasound. It is based on balancing the weight matrix, using the maximum singular values of the target layers in depth without changing the forward model. The performance of the method is evaluated using phantom targets and 10 clinical cases of larger malignant and benign lesions. The results for the homogenous targets demonstrate that the location error of the reconstructed maximum absorption coefficient is reduced to the range of the reconstruction mesh size for phantom targets. Furthermore, the uniformity of absorption distribution inside the lesions improve about two times and the median of the absorption increases from 60 to 85% of its maximum compared to no depth correction. In addition, nonhomogenous phantoms are characterized more accurately. Clinical examples show a similar trend as the phantom results and demonstrate the utility of the correction method for improving lesion quantification.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Behnoosh Tavakoli and Quing Zhu "Depth-correction algorithm that improves optical quantification of large breast lesions imaged by diffuse optical tomography," Journal of Biomedical Optics 16(5), 056002 (1 May 2011). https://doi.org/10.1117/1.3573814

Published: 1 May 2011

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
12 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY