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1 September 2011 Laser speckle contrast imaging of cerebral blood flow in freely moving animals
Peng Miao, Shanbao Tong, Hongyang Lu, Qi Liu, Yao Li
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Journal of Biomedical Optics, Vol. 16, Issue 9, 090502 (September 2011). https://doi.org/10.1117/1.3625231
Abstract
We designed a miniature laser speckle imager that weighs ∼20 g and is 3.1-cm high for full-field high-resolution imaging of cerebral blood flow (CBF) in freely moving animals. Coherent laser light illuminates the cortex through a multimode optical fiber bundle fixed onto the supporting frame of the imager. The reflected lights are then collected by a miniature macrolens system and imaged by a high-resolution CMOS camera at a high frame rate (50 fps). Using this miniature imager, we achieve high spatiotemporal resolution laser speckle contrast imaging of CBF in freely moving animals in real time.
©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Peng Miao, Shanbao Tong, Hongyang Lu, Qi Liu, and Yao Li "Laser speckle contrast imaging of cerebral blood flow in freely moving animals," Journal of Biomedical Optics 16(9), 090502 (1 September 2011). https://doi.org/10.1117/1.3625231
Published: 1 September 2011
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Cited by 79 scholarly publications and 4 patents.
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KEYWORDS
Imaging systems
Speckle
Laser speckle contrast imaging
Cerebral blood flow
Optical fibers
Image processing
Image resolution
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