Three-dimensional photoacoustic tomography based on the focal-line concept

Jun Xia; Zijian Guo; Konstantin I. Maslov; Lihong V. Wang; Andres Aguirre; Quing Zhu; Christopher Percival

doi:10.1117/1.3625576

1 September 2011 Three-dimensional photoacoustic tomography based on the focal-line concept

Jun Xia, Zijian Guo, Konstantin I. Maslov, Lihong V. Wang, Andres Aguirre, Quing Zhu, Christopher Percival

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 9, 090505 (September 2011). https://doi.org/10.1117/1.3625576

Abstract

A full ring ultrasonic array-based photoacoustic tomography system was recently developed for small animal brain imaging. The 512-element array is cylindrically focused in the elevational direction, and can acquire a two-dimensional (2D) image in 1.6 s. In this letter, we demonstrate the three-dimensional (3D) imaging capability of this system. A novel 3D reconstruction algorithm was developed based on the focal-line concept. Compared to 3D images acquired simply by stacking a series of 2D images, the 3D focal-line reconstruction method renders images with much less artifacts, and improves the elevational resolution by 30% and the signal-to-noise ratio by two times. The effectiveness of the proposed algorithm was first validated by numerical simulations and then demonstrated with a hair phantom experiment and an ex vivo mouse embryo experiment.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Jun Xia, Zijian Guo, Konstantin I. Maslov, Lihong V. Wang, Andres Aguirre, Quing Zhu, and Christopher Percival "Three-dimensional photoacoustic tomography based on the focal-line concept," Journal of Biomedical Optics 16(9), 090505 (1 September 2011). https://doi.org/10.1117/1.3625576

Published: 1 September 2011

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