CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 17 > Issue 11 > Article
Open Access
2 November 2012 Refractive index of solutions of human hemoglobin from the near-infrared to the ultraviolet range: Kramers-Kronig analysis
Oleksiy Sydoruk, Olga S. Zhernovaya, Valery V. Tuchin, Alexandre Douplik
Author Affiliations +
Journal of Biomedical Optics, Vol. 17, Issue 11, 115002 (November 2012). https://doi.org/10.1117/1.JBO.17.11.115002
Abstract
Because direct measurements of the refractive index of hemoglobin over a large wavelength range are challenging, indirect methods deserve particular attention. Among them, the Kramers-Kronig relations are a powerful tool often used to derive the real part of a refractive index from its imaginary part. However, previous attempts to apply the relations to solutions of human hemoglobin have been somewhat controversial, resulting in disagreement between several studies. We show that this controversy can be resolved when careful attention is paid not only to the absorption of hemoglobin but also to the dispersion of the refractive index of the nonabsorbing solvent. We present a Kramers-Kroning analysis taking both contributions into account and compare the results with the data from several studies. Good agreement with experiments is found across the visible and parts of near-infrared and ultraviolet regions. These results reinstate the use of the Kramers-Kronig relations for hemoglobin solutions and provide an additional source of information about their refractive index.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
Citation Download Citation
Oleksiy Sydoruk, Olga S. Zhernovaya, Valery V. Tuchin, and Alexandre Douplik "Refractive index of solutions of human hemoglobin from the near-infrared to the ultraviolet range: Kramers-Kronig analysis," Journal of Biomedical Optics 17(11), 115002 (2 November 2012). https://doi.org/10.1117/1.JBO.17.11.115002
Published: 2 November 2012
JOURNAL ARTICLE
 6 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 55 scholarly publications and 1 patent.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Refractive index
Water
Absorption
Ultraviolet radiation
Blood
Biomedical optics
Glucose
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top