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19 November 2012 Indocyanine-green-loaded microballoons for biliary imaging in cholecystectomy
Kinshuk Mitra, James Melvin, Shufang Chang, Ronald Xu, Kyoungjin Park, Alper Yilmaz, Scott Melvin M.D.
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Journal of Biomedical Optics, Vol. 17, Issue 11, 116025 (November 2012). https://doi.org/10.1117/1.JBO.17.11.116025
Abstract
We encapsulate indocyanine green (ICG) in poly[(D,L-lactide-co-glycolide)-co-PEG] diblock (PLGA-PEG) microballoons for real-time fluorescence and hyperspectral imaging of biliary anatomy. ICG-loaded microballoons show superior fluorescence characteristics and slower degradation in comparison with pure ICG. The use of ICG-loaded microballoons in biliary imaging is demonstrated in both biliary-simulating phantoms and an ex vivo tissue model. The biliary-simulating phantoms are prepared by embedding ICG-loaded microballoons in agar gel and imaged by a fluorescence imaging module in a Da Vinci surgical robot. The ex vivo model consists of liver, gallbladder, common bile duct, and part of the duodenum freshly dissected from a domestic swine. After ICG-loaded microballoons are injected into the gallbladder, the biliary structure is imaged by both hyperspectral and fluorescence imaging modalities. Advanced spectral analysis and image processing algorithms are developed to classify the tissue types and identify the biliary anatomy. While fluorescence imaging provides dynamic information of movement and flow in the surgical region of interest, data from hyperspectral imaging allow for rapid identification of the bile duct and safe exclusion of any contaminant fluorescence from tissue not part of the biliary anatomy. Our experiments demonstrate the technical feasibility of using ICG-loaded microballoons for biliary imaging in
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Kinshuk Mitra, James Melvin, Shufang Chang, Ronald Xu, Kyoungjin Park, Alper Yilmaz, and Scott Melvin M.D. "Indocyanine-green-loaded microballoons for biliary imaging in cholecystectomy," Journal of Biomedical Optics 17(11), 116025 (19 November 2012). https://doi.org/10.1117/1.JBO.17.11.116025
Published: 19 November 2012
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KEYWORDS
Luminescence
Tissues
Hyperspectral imaging
Image segmentation
Injuries
Gallbladder
Surgery
CHORUS Article. This article was made freely available starting 19 November 2013
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