Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo

Jun Xia; Muhammad R. Chatni; Konstantin I. Maslov; Zijian Guo; Kun Wang; Mark A. Anastasio; Lihong V. Wang

doi:10.1117/1.JBO.17.5.050506

4 May 2012 Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo

Jun Xia, Muhammad R. Chatni, Konstantin I. Maslov, Zijian Guo, Kun Wang, Mark A. Anastasio, Lihong V. Wang

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Journal of Biomedical Optics, Vol. 17, Issue 5, 050506 (May 2012). https://doi.org/10.1117/1.JBO.17.5.050506

Abstract

We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6 s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.

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Jun Xia, Muhammad R. Chatni, Konstantin I. Maslov, Zijian Guo, Kun Wang, Mark A. Anastasio, and Lihong V. Wang "Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo," Journal of Biomedical Optics 17(5), 050506 (4 May 2012). https://doi.org/10.1117/1.JBO.17.5.050506

Published: 4 May 2012

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