Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography

Muhammad R. Chatni; Jun Xia; Konstantin I. Maslov; Zijian Guo; Kun Wang; Mark A. Anastasio; Lihong V. Wang; Rebecca Sohn; Jeffrey M. Arbeit; Yu Zhang; Younan Xia

doi:10.1117/1.JBO.17.7.076012

6 July 2012 Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography

Muhammad R. Chatni, Jun Xia, Konstantin I. Maslov, Zijian Guo, Kun Wang, Mark A. Anastasio, Lihong V. Wang, Rebecca Sohn, Jeffrey M. Arbeit, Yu Zhang, Younan Xia

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 7, 076012 (July 2012). https://doi.org/10.1117/1.JBO.17.7.076012

Abstract

With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.

Citation Download Citation

Muhammad R. Chatni, Jun Xia, Konstantin I. Maslov, Zijian Guo, Kun Wang, Mark A. Anastasio, Lihong V. Wang, Rebecca Sohn, Jeffrey M. Arbeit, Yu Zhang, and Younan Xia "Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography," Journal of Biomedical Optics 17(7), 076012 (6 July 2012). https://doi.org/10.1117/1.JBO.17.7.076012

Published: 6 July 2012

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY