Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography

Yi Yang; Tianheng Wang; Quing Zhu; Molly Brewer

doi:10.1117/1.JBO.17.9.090503

6 September 2012 Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography

Yi Yang, Tianheng Wang, Quing Zhu, Molly Brewer

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Journal of Biomedical Optics, Vol. 17, Issue 9, 090503 (September 2012). https://doi.org/10.1117/1.JBO.17.9.090503

Abstract

Angle-resolved optical scattering properties of ovarian tissue, on different optical coherence tomography (OCT) imaging planes, were quantitatively measured by fitting the compounded OCT A-lines into a single scattering model. Higher cross correlation value of angle-resolved scattering coefficients between different OCT imaging planes was found in normal ovaries than was present in malignant ovaries. The mean cross correlation coefficient (MCC) was introduced in this pilot study to characterize and differentiate normal, n=6 , and malignant, n=4 , ovaries. A specificity of 100 percent and a sensitivity of 100 percent were achieved by setting MCC threshold at 0.6. Collagen properties, within the OCT imaging penetration depth, were also qualitatively studied in terms of their content, structure and directivity. The homogeneous three-dimensional collagen fiber network, observed in the normal ovary, effectively explains the stronger cross correlation of angle-resolved scattering properties on different imaging planes while the heterogeneity, observed in the malignant ovary, suggests a weaker correlation.

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Yi Yang, Tianheng Wang, Quing Zhu, and Molly Brewer "Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography," Journal of Biomedical Optics 17(9), 090503 (6 September 2012). https://doi.org/10.1117/1.JBO.17.9.090503

Published: 6 September 2012

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