Photoacoustic tomography to identify inflammatory arthritis

Justin R. Rajian; Gandikota Girish; Xueding Wang

doi:10.1117/1.JBO.17.9.096013

14 September 2012 Photoacoustic tomography to identify inflammatory arthritis

Justin R. Rajian, Gandikota Girish, Xueding Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 9, 096013 (September 2012). https://doi.org/10.1117/1.JBO.17.9.096013

Abstract

Identifying neovascularity (angiogenesis) as an early feature of inflammatory arthritis can help in early accurate diagnosis and treatment monitoring of this disease. Photoacoustic tomography (PAT) is a hybrid imaging modality which relies on intrinsic differences in the optical absorption among the tissues being imaged. Since blood has highly absorbing chromophores including both oxygenated and deoxygenated hemoglobin, PAT holds potential in identifying early angiogenesis associated with inflammatory joint diseases. PAT is used to identify changes in the development of inflammatory arthritis in a rat model. Imaging at two different wavelengths, 1064 nm and 532 nm, on rats revealed that there is a significant signal enhancement in the ankle joints of the arthritis affected rats when compared to the normal control group. Histology images obtained from both the normal and the arthritis affected rats correlated well with the PAT findings. Results support the fact that the emerging PAT could become a new tool for clinical management of inflammatory arthritis.

Citation Download Citation

Justin R. Rajian, Gandikota Girish, and Xueding Wang "Photoacoustic tomography to identify inflammatory arthritis," Journal of Biomedical Optics 17(9), 096013 (14 September 2012). https://doi.org/10.1117/1.JBO.17.9.096013

Published: 14 September 2012

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
3 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 39 scholarly publications.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Acquisition tracking and pointing

Ultrasonography

Tissues

Photoacoustic tomography

Photoacoustic spectroscopy

Tissue optics

Blood

Show All Keywords

RELATED CONTENT

Photoacoustic tomography to identify angiogenesis for diagnosis and treatment monitoring...
Proceedings of SPIE (March 04 2013)

Deep penetrating photoacoustic tomography in biological tissues
Proceedings of SPIE (April 25 2005)

Quantitative photoacoustic tomography recovery of optical absorption coefficient maps...
Proceedings of SPIE (February 13 2007)

Absolute measurements of local chromophore concentrations using pulsed photoacoustic spectroscopy
Proceedings of SPIE (March 06 2006)

Simultaneous recovery of chromophore concentrations and ultrasound velocity by spectrally...
Proceedings of SPIE (February 12 2009)

Investigation of a diffuse optical tomography assisted quantitative photoacoustic tomography...
Proceedings of SPIE (February 17 2011)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years