Near-infrared fluorescence goggle system with complementary metal–oxide–semiconductor imaging sensor and see-through display

Yang Liu; Raphael Njuguna; Thomas Matthews; Walter J. Akers; Gail P. Sudlow; Suman B. Mondal; Rui Tang; Viktor Gruev; Samuel Achilefu

doi:10.1117/1.JBO.18.10.101303

31 May 2013 Near-infrared fluorescence goggle system with complementary metal–oxide–semiconductor imaging sensor and see-through display

Yang Liu, Raphael Njuguna, Thomas Matthews, Walter J. Akers, Gail P. Sudlow, Suman B. Mondal, Rui Tang, Viktor Gruev, Samuel Achilefu

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Journal of Biomedical Optics, Vol. 18, Issue 10, 101303 (May 2013). https://doi.org/10.1117/1.JBO.18.10.101303

Abstract

We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal–oxide–semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in real time. The goggle is capable of detecting fluorescence of indocyanine green solution in the picomolar range. Aided by NIR quantum dots, we successfully used the fluorescence goggle to guide sentinel lymph node mapping in a rat model. We further demonstrated the feasibility of using the fluorescence goggle in guiding surgical resection of breast cancer metastases in the liver in conjunction with NIR fluorescent probes. These results illustrate the diverse potential use of the goggle system in surgical procedures.

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Yang Liu, Raphael Njuguna, Thomas Matthews, Walter J. Akers, Gail P. Sudlow, Suman B. Mondal, Rui Tang, Viktor Gruev, and Samuel Achilefu "Near-infrared fluorescence goggle system with complementary metal–oxide–semiconductor imaging sensor and see-through display," Journal of Biomedical Optics 18(10), 101303 (31 May 2013). https://doi.org/10.1117/1.JBO.18.10.101303

Published: 31 May 2013

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