Ultrasound-heated photoacoustic flowmetry

Lidai Wang; Junjie Yao; Konstantin I. Maslov; Wenxin Xing; Lihong V. Wang

doi:10.1117/1.JBO.18.11.117003

5 November 2013 Ultrasound-heated photoacoustic flowmetry

Lidai Wang, Junjie Yao, Konstantin I. Maslov, Wenxin Xing, Lihong V. Wang

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Journal of Biomedical Optics, Vol. 18, Issue 11, 117003 (November 2013). https://doi.org/10.1117/1.JBO.18.11.117003

Abstract

We report the development of photoacoustic flowmetry assisted by high-intensity focused ultrasound (HIFU). This novel method employs HIFU to generate a heating impulse in the flow medium, followed by photoacoustic monitoring of the thermal decay process. Photoacoustic flowmetry in a continuous medium remains a challenge in the optical diffusive regime. Here, both the HIFU heating and photoacoustic detection can focus at depths beyond the optical diffusion limit (∼1 mm in soft tissue). This method can be applied to a continuous medium, i.e., a medium without discrete scatterers or absorbers resolvable by photoacoustic imaging. Flow speeds up to 41 mm⋅s ⁻¹ have been experimentally measured in a blood phantom covered by 1.5-mm-thick tissue.

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Lidai Wang, Junjie Yao, Konstantin I. Maslov, Wenxin Xing, and Lihong V. Wang "Ultrasound-heated photoacoustic flowmetry," Journal of Biomedical Optics 18(11), 117003 (5 November 2013). https://doi.org/10.1117/1.JBO.18.11.117003

Published: 5 November 2013

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