CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 18 > Issue 12 > Article
Open Access
23 December 2013 Contrast enhanced-magnetic resonance imaging as a surrogate to map verteporfin delivery in photodynamic therapy
Kimberley S. Samkoe, Amber Bryant, Jason R. Gunn, Stephen P. Pereira, Tayyaba Hasan, Brian W. Pogue
Author Affiliations +
Journal of Biomedical Optics, Vol. 18, Issue 12, 120504 (December 2013). https://doi.org/10.1117/1.JBO.18.12.120504
Abstract
The use of in vivo contrast-enhanced magnetic resonance (MR) imaging as a surrogate for photosensitizer (verteporfin) dosimetry in photodynamic therapy of pancreas cancer is demonstrated by correlating MR contrast uptake to ex vivo fluorescence images on excised tissue. An orthotopic pancreatic xenograft mouse model was used for the study. A strong correlation ([i]r=0.57 ) was found for bulk intensity measurements of T1-weighted gadolinium enhancement and verteporfin fluorescence in the tumor region of interest. The use of contrast-enhanced MR imaging shows promise as a method for treatment planning and photosensitizer dosimetry in human photodynamic therapy (PDT) of pancreas cancer.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Citation Download Citation
Kimberley S. Samkoe, Amber Bryant, Jason R. Gunn, Stephen P. Pereira, Tayyaba Hasan, and Brian W. Pogue "Contrast enhanced-magnetic resonance imaging as a surrogate to map verteporfin delivery in photodynamic therapy," Journal of Biomedical Optics 18(12), 120504 (23 December 2013). https://doi.org/10.1117/1.JBO.18.12.120504
Published: 23 December 2013
JOURNAL ARTICLE
 4 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 5 scholarly publications.
Advertisement
Advertisement
KEYWORDS
Tumors
Magnetic resonance imaging
Photodynamic therapy
Tissues
Luminescence
Resonance enhancement
Gadolinium
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top