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12 February 2013 Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium
Joseph L. Hollmann, Roarke Horstmeyer, Changhuei Yang, Charles A. DiMarzio
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Journal of Biomedical Optics, Vol. 18, Issue 2, 025004 (February 2013). https://doi.org/10.1117/1.JBO.18.2.025004
Abstract
The effects of strong scattering in tissue limit the depth to which light may be focused. However, it has been shown that scattering may be reduced utilizing adaptive optics with a focused ultrasound (US) beam guidestar. The optical signal traveling through the US beam waist is frequency shifted and may be isolated with demodulation. This paper utilizes a multiphysics simulation to model the optical and US interactions in both synthetic tissue and random scattering media. The results illustrate that optical energy may be focused within a turbid medium utilizing a US guidestar. The results also suggest that optical energy travels preferentially along optical channels within a turbid medium.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2013/$25.00 © 2013 SPIE
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Joseph L. Hollmann, Roarke Horstmeyer, Changhuei Yang, and Charles A. DiMarzio "Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium," Journal of Biomedical Optics 18(2), 025004 (12 February 2013). https://doi.org/10.1117/1.JBO.18.2.025004
Published: 12 February 2013
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KEYWORDS
Tissue optics
Phase conjugation
Scattering
Channel projecting optics
Modulation
Adaptive optics
Tissues
CHORUS Article. This article was made freely available starting 12 February 2014
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