Optical resolution photoacoustic microendoscopy with ultrasound-guided insertion and array system detection

Parsin Hajireza; Tyler J. Harrison; Alexander Forbrich; Roger J. Zemp

doi:10.1117/1.JBO.18.9.090502

25 September 2013 Optical resolution photoacoustic microendoscopy with ultrasound-guided insertion and array system detection

Parsin Hajireza, Tyler J. Harrison, Alexander Forbrich, Roger J. Zemp

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Journal of Biomedical Optics, Vol. 18, Issue 9, 090502 (September 2013). https://doi.org/10.1117/1.JBO.18.9.090502

Abstract

Using a 0.8-mm-diameter image guide fiber bundle consisting of 30,000 single-mode fibers and an external linear array transducer, we demonstrate a dual-mode photoacoustic system capable of ultrasound-guided microendoscope insertion and photoacoustic imaging. The array optical resolution photoacoustic microendoscopy (AOR-PAME) system is designed to visualize the placement of the distal end of an endoscopy probe several centimeters into tissue, transmit scanning focused laser pulses into tissues via the fiber bundle, and acquire the generated photoacoustic signals. A ytterbium-doped fiber laser is tightly focused and is scanned across the proximal tip of the image guide fiber bundle using a two-dimensional galvanometer scanning mirror system. The end of the fiber bundle is used in contact mode with the object. The capabilities of AOR-PAME are demonstrated by imaging carbon fiber networks embedded in tissue-mimicking phantoms and the ears of a 60-g rat. The lateral resolution and signal-to-noise ratio are measured as 9 μm and 40 dB, respectively.

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Parsin Hajireza, Tyler J. Harrison, Alexander Forbrich, and Roger J. Zemp "Optical resolution photoacoustic microendoscopy with ultrasound-guided insertion and array system detection," Journal of Biomedical Optics 18(9), 090502 (25 September 2013). https://doi.org/10.1117/1.JBO.18.9.090502

Published: 25 September 2013

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