Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

Thu-Mai Nguyen; Shaozhen Song; Bastien Arnal; Emily Y. Wong; Zhihong Huang; Ruikang K. Wang; Matthew O'Donnell

doi:10.1117/1.JBO.19.1.016013

17 January 2014 Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

Thu-Mai Nguyen, Shaozhen Song, Bastien Arnal, Emily Y. Wong, Zhihong Huang, Ruikang K. Wang, Matthew O'Donnell

Author Affiliations +

Journal of Biomedical Optics, Vol. 19, Issue 1, 016013 (January 2014). https://doi.org/10.1117/1.JBO.19.1.016013

Abstract

Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (<12 dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Thu-Mai Nguyen, Shaozhen Song, Bastien Arnal, Emily Y. Wong, Zhihong Huang, Ruikang K. Wang, and Matthew O'Donnell "Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography," Journal of Biomedical Optics 19(1), 016013 (17 January 2014). https://doi.org/10.1117/1.JBO.19.1.016013

Published: 17 January 2014

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY