Photoacoustic measurement of the Grüneisen parameter of tissue

Da-Kang Yao; Chi Zhang; Konstantin I. Maslov; Lihong V. Wang

doi:10.1117/1.JBO.19.1.017007

28 January 2014 Photoacoustic measurement of the Grüneisen parameter of tissue

Da-Kang Yao, Chi Zhang, Konstantin I. Maslov, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 19, Issue 1, 017007 (January 2014). https://doi.org/10.1117/1.JBO.19.1.017007

Abstract

The Grüneisen parameter, a constitutive parameter in photoacoustics, is usually measured from isobaric thermal expansion, which may not be valid for a biological medium due to its heterogeneity. Here, we directly measured the Grüneisen parameter by applying photoacoustic spectroscopy. Laser pulses at wavelengths between 460 and 1800 nm were delivered to tissue samples, and photoacoustic signals were detected by flat water-immersion ultrasonic transducers. Least-squares fitting photoacoustic spectra to molar optical absorption spectra showed that the Grüneisen parameter was 0.81±0.05 (mean±SD ) for porcine subcutaneous fat tissue and 0.69±0.02 for porcine lipid at room temperature (22°C). The Grüneisen parameter of a red blood cell suspension was linearly related to hemoglobin concentration, and the parameter of bovine serum was 9% greater than that of water at room temperature.

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Da-Kang Yao, Chi Zhang, Konstantin I. Maslov, and Lihong V. Wang "Photoacoustic measurement of the Grüneisen parameter of tissue," Journal of Biomedical Optics 19(1), 017007 (28 January 2014). https://doi.org/10.1117/1.JBO.19.1.017007

Published: 28 January 2014

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KEYWORDS

Photoacoustic spectroscopy

Absorption

Tissue optics

Transducers

Blood

Tissues

Ultrasonics

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