Tryptophan as the fingerprint for distinguishing aggressiveness among breast cancer cell lines using native fluorescence spectroscopy

Lin Zhang; Yang Pu; Jianpeng Xue; Sebastião Pratavieira; Baogang Xu; Samuel Achilefu; Robert R. Alfano

doi:10.1117/1.JBO.19.3.037005

27 March 2014 Tryptophan as the fingerprint for distinguishing aggressiveness among breast cancer cell lines using native fluorescence spectroscopy

Lin Zhang, Yang Pu, Jianpeng Xue, Sebastião Pratavieira, Baogang Xu, Samuel Achilefu, Robert R. Alfano

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Journal of Biomedical Optics, Vol. 19, Issue 3, 037005 (March 2014). https://doi.org/10.1117/1.JBO.19.3.037005

Abstract

Tryptophan is investigated as the key native marker in cells to determine the level of metastasis competence in breast cell lines using native fluorescence spectroscopy. The ratio of fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. We found that the fluorescence of aggressive breast cancer cell has a much higher contribution from tryptophan compared with that from the normal cells and nonaggressive breast cancer cell.

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Lin Zhang, Yang Pu, Jianpeng Xue, Sebastião Pratavieira, Baogang Xu, Samuel Achilefu, and Robert R. Alfano "Tryptophan as the fingerprint for distinguishing aggressiveness among breast cancer cell lines using native fluorescence spectroscopy," Journal of Biomedical Optics 19(3), 037005 (27 March 2014). https://doi.org/10.1117/1.JBO.19.3.037005

Published: 27 March 2014

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