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2 December 2013 In vivo imaging of human adipose-derived stem cells in Alzheimer’s disease animal model
Sungji Ha, Sangzin Ahn, Saeromi Kim, Yuyoung Joo, Young Hae Chong, Yoo-Hun Suh, Keun-A Chang
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Journal of Biomedical Optics, Vol. 19, Issue 5, 051206 (December 2013). https://doi.org/10.1117/1.JBO.19.5.051206
Abstract
Stem cell therapy is a promising tool for the treatment of diverse conditions, including neurodegenerative diseases such as Alzheimer’s disease (AD). To understand transplanted stem cell biology, in vivo imaging is necessary. Nanomaterial has great potential for in vivo imaging and several noninvasive methods are used, such as magnetic resonance imaging, positron emission tomography, fluorescence imaging (FI) and near-infrared FI. However, each method has limitations for in vivo imaging. To overcome these limitations, multimodal nanoprobes have been developed. In the present study, we intravenously injected human adipose-derived stem cells (hASCs) that were labeled with a multimodal nanoparticle, LEO-LIVE™-Magnoxide 675 or 797 (BITERIALS, Seoul, Korea), into Tg2576 mice, an AD mouse model. After sequential in vivo tracking using Maestro Imaging System, we found fluorescence signals up to 10 days after injection. We also found strong signals in the brains extracted from hASC-transplanted Tg2576 mice up to 12 days after injection. With these results, we suggest that in vivo imaging with this multimodal nanoparticle may provide a useful tool for stem cell tracking and understanding stem cell biology in other neurodegenerative diseases.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Sungji Ha, Sangzin Ahn, Saeromi Kim, Yuyoung Joo, Young Hae Chong, Yoo-Hun Suh, and Keun-A Chang "In vivo imaging of human adipose-derived stem cells in Alzheimer’s disease animal model," Journal of Biomedical Optics 19(5), 051206 (2 December 2013). https://doi.org/10.1117/1.JBO.19.5.051206
Published: 2 December 2013
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Cited by 21 scholarly publications.
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KEYWORDS
In vivo imaging
Stem cells
Brain
Nanoparticles
Luminescence
Alzheimer's disease
Imaging systems
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