Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain

Kyle Nadeau; Anthony J. Durkin; Bruce J. Tromberg

doi:10.1117/1.JBO.19.5.056013

23 May 2014 Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain

Kyle Nadeau, Anthony J. Durkin, Bruce J. Tromberg

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Journal of Biomedical Optics, Vol. 19, Issue 5, 056013 (May 2014). https://doi.org/10.1117/1.JBO.19.5.056013

Abstract

We have developed a method for extracting spatial frequency information content from biological tissue, which is used to calculate tissue optical properties and determine tissue structural orientation. This demodulation method employs a two-dimensional Hilbert transform using a spiral phase function in Fourier space. The approach presented here allows for the determination of tissue optical properties using a single frame of data for each modulation frequency, increasing imaging speed by two to threefold versus conventional, three-phase spatial frequency domain imaging (SFDI). This new single-phase Hilbert transform approach recovers optical property and scattering orientation index values within 1% and 10% of three-phase SFDI, respectively. These results suggest that, using the Hilbert demodulation technique, SFDI data acquisition speed can be increased significantly while preserving data quality, which will help us move forward toward the implementation of a real-time SFDI platform.

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Kyle Nadeau, Anthony J. Durkin, and Bruce J. Tromberg "Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain," Journal of Biomedical Optics 19(5), 056013 (23 May 2014). https://doi.org/10.1117/1.JBO.19.5.056013

Published: 23 May 2014

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