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21 May 2014 Towards clinical use of a laser-induced microjet system aimed at reliable and safe drug delivery
Hun-jae Jang, Hyeonju Yu, Seonggeun Lee, Eugene Hur, Yoonkwan Kim, Seol-Hoon Lee, Naegyu Kang, Jack J. Yoh
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Journal of Biomedical Optics, Vol. 19, Issue 5, 058001 (May 2014). https://doi.org/10.1117/1.JBO.19.5.058001
Abstract
An Er:YAG laser with 2940-nm wavelength and 250-μs pulse duration is used to generate a microjet that is ejected at ∼50  m/s in air. The strength of the microjet depends on the bubble dynamics from the beam–water interaction within the driving chamber as well as the discharging of the drug solution underneath the elastic membrane that separates the drug from the driving liquid. The jet characteristics, such as velocity, volume, and level of atomization, are obtained by high-speed camera images taken at 42,000 fps. The enhancements in jet volume (dosage) and repeated jet generation, which are aimed at making the injector suitable for general clinical applications, are achieved. The generation of repeated microjets is achieved with the help of a stepping motor that provides a uniform pressure within the drug reservoir before an ejection occurs through a micro nozzle. Also, two types of human growth hormones are used for monitoring any potential thermal damage to the drug solution due to a repeated laser ablation when driving the microjet. We provide strong evidence to support that the drugs, as they are injected to porcine skins, are free of the damage associated with the present delivery method.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Hun-jae Jang, Hyeonju Yu, Seonggeun Lee, Eugene Hur, Yoonkwan Kim, Seol-Hoon Lee, Naegyu Kang, and Jack J. Yoh "Towards clinical use of a laser-induced microjet system aimed at reliable and safe drug delivery," Journal of Biomedical Optics 19(5), 058001 (21 May 2014). https://doi.org/10.1117/1.JBO.19.5.058001
Published: 21 May 2014
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Cited by 23 scholarly publications.
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KEYWORDS
Laser systems engineering
Laser ablation
Laser safety
Er:YAG lasers
Liquids
Skin
Chemical analysis
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