Blood typing using microstructured waveguide smart cuvette

Anastasiya A. Zanishevskaya; Andrey A. Shuvalov; Yulia S. Skibina; Valery V. Tuchin

doi:10.1117/1.JBO.20.4.040503

13 April 2015 Blood typing using microstructured waveguide smart cuvette

Anastasiya A. Zanishevskaya, Andrey A. Shuvalov, Yulia S. Skibina, Valery V. Tuchin

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Journal of Biomedical Optics, Vol. 20, Issue 4, 040503 (April 2015). https://doi.org/10.1117/1.JBO.20.4.040503

Abstract

We introduce a sensitive method that allows one to distinguish positive and negative agglutination reactions used for blood typing and determination of Rh affinity with a high precision. The method is based on the unique properties of photonic crystal waveguides, i.e., microstructured waveguides (MSWs). The transmission spectrum of an MSW smart cuvette filled by a specific or nonspecific agglutinating serum depends on the scattering, refractive, and absorptive properties of the blood probe. This concept was proven in the course of a laboratory clinical study. The obtained ratio of the spectral-based discrimination parameter for positive and negative reactions (I+/I−) was found to be 16 for standard analysis and around 2 for used sera with a weak activity.

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Anastasiya A. Zanishevskaya, Andrey A. Shuvalov, Yulia S. Skibina, and Valery V. Tuchin "Blood typing using microstructured waveguide smart cuvette," Journal of Biomedical Optics 20(4), 040503 (13 April 2015). https://doi.org/10.1117/1.JBO.20.4.040503

Published: 13 April 2015

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